A self-calibrating deep space tracking technique is described which can potentially produce two nanoradian angular spacecraft determinations. The technique uses very long base interferometric observations of a spacecraft and several radio sources. The currently employed single source technique is described as a parameter estimation procedure. Then, the number of parameters and observations leads to the proposed local reference frame technique. Station clock, Earth rotation, and tropospheric parameters are estimated along with spacecraft position from the multisource observation sequence. The contributions to spacecraft angular uncertainty from system noise, tropospheric fluctuations, and uncalibrated radio source structure are evaluated. Of these experimental errors, radio source structure dominates the determination of the spacecraft position in the radio reference frame. It is shown, however, that the sensitivity of relative spacecraft position accuracies to time-invariant radio source structure effects may be on the order of 2 nanoradians.